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JOANN M. GATES, M.D.; ANNE U. BARNES, M.D.; GEORGE C. HENEGAR, M.D.; FREDERICK W. PRESTON, M.D.

AMA Arch Surg. 1958;77(3):336-344.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Fat emulsions have been investigated extensively in an effort to find a safe source of calories for malnourished patients being maintained on parenteral feeding for prolonged periods. However, little attention has been paid to the effect of these emulsions on liver function. In view of the major role of the liver in intermediary fat metabolism and the frequent occurrence of accumulation of fat within the hepatic parenchyma, it seemed of interest to investigate the effects of repeated infusions of fat on the functions and structure of the liver.

Methods

Daily infusions of 600 ml. of a fat emulsion were given to 20 hospitalized male patients. Ten patients had normal and 10 had abnormal liver function prior to the infusions, as judged by sulfobromophthalein U. S. P. (Bromsulphalein) retention. The patients were selected on the basis of their cooperativeness and their availability for biopsies and follow-up studies.

The fat emulsion (Lipomul-I. . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Departments of Surgery, Veterans' Administration Research Hospital and Northwestern University Medical School.

Footnotes
Submitted for publication March 28, 1958.

Read at the 15th Annual Assembly of the Central Surgical Association, Columbus, Ohio, Feb. 20, 1958.

Supported by a grant from The Upjohn Company. The fat emulsion, Lipomul-I. V., was furnished through the courtesy of Dr. E. A. Hawk, The Upjohn Company.

Miss Elizabeth Jane Jackson gave technical assistance, and Dr. Jeanne Cooper, Department of Pathology, Veterans' Administration Research Hospital, reviewed the microscopic sections.

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