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HARRY A. OBERHELMAN, Jr., M.D.; THOMAS S. NELSEN, M.D.; LESTER R. DRAGSTEDT, M.D., Ph.D.

AMA Arch Surg. 1958;77(3):402-415.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The association of progressive and recurrent peptic ulceration with non-insulin-producing islet-cell tumors of the pancreas was first observed by Zollinger and Ellison in 1955.¹ In 1956² Ellison reviewed 24 cases of ulcerogenic tumors of the pancreatic islets from various sources and characterized this new clinical syndrome. It consisted of a hypersecretion of gastric juice with progressive peptic ulceration, recurring despite adequate medical and surgical therapy, and the presence of non-insulin-producing islet-cell tumors of the pancreas. The ulcers were frequently located in atypical sites, such as the jejunum and distal duodenum, as well as the esophagus, stomach, and duodenal bulb. Symptoms were usually referable to the ulcer and its complications and frequently resulted in death. The majority of these islet-cell tumors were considered malignant and in most instances consisted of cells devoid of beta granules, suggesting that they might be of alpha-cell origin. Since glucagon, or hyperglycemic-glycogenolytic factor, is . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Surgery, The University of Chicago.

Footnotes
Submitted for publication March 28, 1958.

Read at the 15th Annual Assembly of the Central Surgical Association, Columbus, Ohio, Feb. 21, 1958.

This work has been aided by grants from the Otho S. A. Sprague Memorial Institute and from the Division of Research Grants and Fellowships, National Institutes of Health.

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