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Clinical Use of Intravenous Fat in Surgical Patients
WILLIAM H. MARSHALL, M.D.
AMA Arch Surg. 1959;78(6):851-855.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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An intravenous fat emulsion (Lipomul I. V.) has recently become available for clinical use. Utilizing a 15% emulsion of cottonseed oil with soybean phosphatides and Pleuronic F-68 ( oxyethyleneoxypropylene polymer) as stabilizers, it is prepared with 4% dextrose in water as a vehicle.1 A preliminary report from the surgical service of the Illinois Research and Educational Hospitals2 indicated that this improved fat emulsion was sufficiently free of side-effects to make it safe for routine clinical use. The most prominent reactions noted in this study were a transient minor hypertensive response in 48% of infusions and a transient temperature elevation in 1.6% of patients.
Studies on this preparation have since been extended to include an additional 95 patients, who have received a total of 580 units of intravenous fat for an average consumption of 6 units per patient. Each unit contained 500 or 600 cc. of fat emulsion, depending on
. . . [Full Text PDF of this Article]
Author Affiliations
Chicago
Footnotes
Read at the 66th Annual Meeting of the Western Surgical Association, Rochester, Minn., May 21, 1958.
The fat emulsion used in this series of patients was kindly furnished by The Upjohn Company, Kalamazoo, Mich.
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