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Method for Metabolic Studies in Animals

RICHARD L. DAKIN, M.D.; JACK JEW, M.D.; HAROLD A. HARPER, Ph.D.; H. J. McCORKLE, M.D.

AMA Arch Surg. 1959;78(6):856-861.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Evidence for the specific contribution of the liver to a metabolic process has in the past been obtained by studies in animals after total hepatectomy. Because the physiological status of the animal is progressively impaired following hepatectomy, it seems desirable to utilize a procedure whereby the blood supply might be temporarily excluded from and then returned to the liver. The subsequent survival of the animal would then indicate the viability of the extrahepatic tissues during the period of isolation of the liver from its vascular supply. Under these circumstances the hepatic contribution to the metabolism of a given substance could be evaluated by a comparison of its utilization before, during, and after exclusion of the liver from the circulatory system.

Mann,¹ in 1921, described a three-stage procedure for total removal of the liver. In the first stage of his procedure a side-to-side portacaval anastomosis was made, followed by ligation . . . [Full Text PDF of this Article]

Author Affiliations
San Francisco

From the Surgical Research Laboratories and the Department of Surgery of the University of California School of Medicine.

Footnotes
Read at the 66th Annual Meeting of the Western Surgical Association, Rochester, Minn., Nov. 21, 1958.

Supported by a grant from the National Institute for Arthritis and Metabolic Diseases, USPHS A-1053, and the Christine Breon Fund for Medical Research.

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