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Prediction of Mortality Following Acute Measured Hemorrhage in the Dog

HENRY SWAN, M.D.; JEAN BLAVIER, M.D.; THOMAS MARCHIORO, M.D.; DALTON JENKINS, M.D.; VERNON MONTGOMERY, M.D., Ph.D.

AMA Arch Surg. 1959;79(2):176-184.

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Introduction

Heretofore, studies of the effects of hemorrhage on animals have been inextricably associated with studies of shock. A few workers have reported experiments in which the independent variable was the loss of varying volumes of blood,^1,2 but their goal was either to produce or to elucidate some mechanism of shock. Walcott¹ determined the blood volume of dogs by means of Evans blue (T-1824) and the centrifuged hematocrit. These dogs were bled from their femoral artery 41% to 58% of their measured blood volume. He found that all animals died when bled 53% or more of their blood volume. Roughly 50% of the animals bled a smaller per cent of blood volume survived. In a later paper, however, Walcott³ states that bleeding an animal according to a fixed percentage of blood volume is an unreliable means of producing shock. Thereafter, Walcott used a modification of Mann's⁴ . . . [Full Text PDF of this Article]

Author Affiliations
Denver

From the Halsted Laboratory of Experimental Surgery and the Departments of Surgery and Medicine, University of Colorado School of Medicine.

Footnotes
Submitted for publication Feb. 27, 1959.

Read at the 16th Annual Assembly of the Central Surgical Association, Montreal, Feb. 19, 1959.

This study was supported in part by a research contract (DA-49-007-MD-572) with the Surgeon General, United States Army.

This work was partially done during the tenure of an Advanced Research Fellowship of the American Heart Association (Dr. Montgomery).

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