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Effect of an Intravenous Fat Emulsion on Blood Coagulation
JOSEPH A. WERR, M.D.;
FREDERICK W. PRESTON, M.D.
AMA Arch Surg. 1959;79(2):213-221.
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The use of intravenous emulsions has been limited by the high incidence of reactions associated with the injection of these substances into the blood stream. The reactions most frequently observed have occurred within a few minutes to several hours after beginning the infusions. The commonest of these is febrile in nature, often accompanied by a chill. More serious is the colloid reaction, thought to be caused by the introduction of colloids into the blood stream. Other toxic effects include anorexia, nausea, vomiting, headaches, dizziness, and vasomotor phenomena.
Early reactions of this type to an improved 15% cottonseed oil emulsion * have been of minor consequence. This has encouraged extensive clinical trials with this emulsion and has made possible its administration for many consecutive days. The low toxicity and metabolic effects of this emulsion are documented in recent published reports.5,7,9,11,12,17
Late reactions may occur in patients who have been given repeated
. . . [Full Text PDF of this Article]
Author Affiliations
Chicago
From the Departments of Surgery, Northwestern University Medical School and the Veterans Administration Research Hospital.
Footnotes
Submitted for publication Feb. 27, 1959.
Read at the 16th Annual Meeting of the Central Surgical Association, Montreal, Feb. 19, 1959.
Aided by a grant from the Upjohn Company, Kalamazoo, Michigan. The fat emulsion, Lipomul I. V., was furnished through the courtesy of Dr. E. A. Hawk and Dr. J. B. Lawson of the Upjohn Company.
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