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RICHARD D. SAUTTER, M.D.; SIDNEY E. ZIFFREN, M.D.

AMA Arch Surg. 1959;79(2):346-356.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The medical profession has become aware of complications that occur in patients suffering from disease of the gastrointestinal tract who receive adrenocortical steroid therapy. For instance, perforations occur in patients who have duodenal ulcer,^5,11,12,17 regional enteritis,^15,16 and ulcerative colitis.^{4, 16,19} But physicians have been much less aware of complications that can occur in patients who give no previous history or present no symptoms or signs of gastrointestinal disease and who receive adrenocortical hormones.

It has been previously noted that the following complications may occur in patients with no previous gastrointestinal disease: production of peptic ulcer^5,8,12,14; perforation of peptic ulcer of the stomach or duodenum^4,7,17; bleeding from the stomach or duodenum from ulcer or gastritis^2,16; development of ulcerative esophagitis¹⁶; development of acute pancreatitis or peripancreatic fat necrosis,³ and perforation of the cecum.¹⁰ There are some internists who do not believe that corticotropin . . . [Full Text PDF of this Article]

Author Affiliations
Iowa City

From the Department of Surgery, State University of Iowa College of Medicine.

Footnotes
Submitted for publication Feb. 27, 1959.

Read at the 16th Annual Meeting of the Central Surgical Association, Montreal, Feb. 20, 1959.

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