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ANGUS D. McLACHLIN, M.D.

AMA Arch Surg. 1959;79(3):393-398.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Familial intestinal polyposis is a hereditary disease complex with a predilection to cancer of the colon or rectum at an early age. Saint¹ made a clear distinction between this familial group, in which the polyps are adenomatous, and another group on the basis of glandular hyperplasia produced by inflammation or some form of local irritation.

The familial group has been studied intensively by Lockhart-Mummery,² Lockhart-Mummery and Dukes,³ and Dukes,⁴ at St. Mark's Hospital in London, England. They believe the disease due to a gene mutation capable of producing an excessive proliferation of the glandular epithelium in the mucous membrane of the colon and rectum. It is not congenital but appears usually after 10 years of age. The polyps increase in number and size and may cause a blood-stained mucous diarrhea along with weight loss and anemia. The same mutation that produced the polyps can, as a . . . [Full Text PDF of this Article]

Author Affiliations
London, Ontario, Canada

From the Department of Surgery, University of Western Ontario.

Footnotes
Submitted for publication Feb. 27, 1959.

Read at the 16th Annual Meeting of the Central Surgical Association, Montreal, Feb. 20, 1959.

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