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EDWARD E. MASON, M.D., Ph.D.; JOHN W. WARD, M.D.; CHRISTA DIERKS, Ph.D.; Ursula Mauch; Vera Polehna; Roderick E. Kellogg

AMA Arch Surg. 1960;81(2):186-192.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Despite numerous studies of morphologic and functional changes in acute renal insufficiency, there is still no adequate means of determining kidney damage early while that damage is developing, and there is still no means of determining the relative importance of a variety of suspected causal factors. As a result the clinician is hampered in establishing an early diagnosis and prognosis, and has no way of evaluating therapy. In reviewing the extensive literature on the subject, one is impressed by the complexity of the problem, the large number of variables involved, and the seeming hopelessness of drawing any further conclusions without finding some simpler experimental approach for testing hypotheses. For this reason a series of experiments have been carried out through use of (1) the isolated perfused kidney, (2) a limited number of potential noxious variables, and (3) analyses of perfusate and urine for cellular moieties as indices of kidney damage. . . . [Full Text PDF of this Article]

Author Affiliations
Iowa City

Footnotes
Read at the 17th Annual Meeting of the Central Surgical Association, Chicago, Feb. 18, 1960.

This investigation was supported by a research grant, RG6500, from the Division of General Medical Sciences, U.S. Public Health Service.

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