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Influence of Hepatectomy and Hepatic Necrosis on Electrophoresis of Plasma Proteins
THEODORE DRAPANAS, M.D.;
DAVID N. KLUGE, M.D.;
WORTHINGTON G. SCHENK, Jr., M.D.;
MANUEL SCHREIBER, Ph.D.;
JOHN D. STEWART, M.D.
AMA Arch Surg. 1960;81(2):327-333.
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With the advent of physicochemical methods of preparative chromatography and electrophoresis, considerable information relating to plasma protein patterns in normal and disease states has evolved.12
Although it appears that the liver is the source of all the plasma albumin, fibrinogen, and most of the globulin,6 its role in the aberration of these protein patterns in disease as shown by electrophoresis has not been clearly defined. It remains unclear whether abnormal patterns are due to lack of formation of proteins by the liver, to the formation of abnormal proteins either by the liver or by the extrahepatic tissues, or to the conjugation of normal proteins with abnormal metabolites, thereby altering their physical properties.
To aid in answering these questions, the changes in the electrophoretic patterns of the plasma proteins were studied for varying periods following surgical removal of all or part of the liver and after chemical hepatic necrosis
. . . [Full Text PDF of this Article]
Author Affiliations
Buffalo
From the Department of Surgery, Edward J. Meyer Memorial Hospital and the University of Buffalo Medical School.; Formerly Special Research Fellow, United States Public Health Service, National Institute of Arthritis and Metabolic Diseases (Dr. Drapanas).
Footnotes
Read at the 17th Annual Meeting of the Central Surgical Association, Chicago, Feb. 19, 1960.
This work supported by a grant-in-aid from the U.S. Public Health Service (H-613) and American Cancer Society Institutional Grant (2N2A).
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