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Two Tumors of High Ulcerogenic Potential

BERNARD C. GERBER, M.D.; THOMAS W. SHIELDS, M.D.

AMA Arch Surg. 1960;81(3):379-388.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The clinical entity of fulminating peptic ulceration associated with gastric hypersecretion and non-beta islet-cell tumors of the pancreas was first described in 1955 by Zollinger and Ellison.¹ Since the original report over 80 cases of the syndrome have been recorded.² Many of the early cases were discovered only on autopsy. However, with an increased awareness of the possibility of the existence of the entity, the diagnosis has been entertained preoperatively, and operative search and removal of the offending islet-cell tumor has been more frequently carried out. The discovery and resection of the non-beta islet-cell tumors has resulted in a marked reduction of gastric hypersecretion and apparent cure of the ulcer diathesis in some patients. However, is a few, the removal of the tumor, as well as appropriate gastric surgery, has failed to terminate the unrelenting progress of severe gastrointestinal ulceration. The continuance of the fulminating ulcer diathesis has . . . [Full Text PDF of this Article]

Author Affiliations
Aberdeen, S.D.; Chicago

From the Department of Surgery, Northwestern University Medical School and Passavant Memorial Hospital, Chicago.; Aberdeen Medical Center, Aberdeen, S.D. (Dr. Gerber, formerly Allen B. Kanavel Fellow in Surgery, Northwestern University Medical School.)

Footnotes
Read at the 17th Annual Meeting of the Central Surgical Association, Chicago, Feb. 20, 1960.

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