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LAWRENCE S. MANN, M.D.; MYRON J. LEVIN, M.D.

AMA Arch Surg. 1960;81(5):690-698.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Respiratory depression was not noted by the authors in more than 100 previous cases where neomycin had been instilled in the human peritoneal cavity (200 ml. of a 1% solution), but tidal volume measurements were not made in these instances.¹ Pridgen² reported four cases of respiratory arrest in which 0.5 gm. was instilled intraperitoneally in each of two infants and 3 gm. in each of two adults. The infants died. The adults survived after undergoing 3 and 48 hours of respiratory depression, respectively. Poth has noted respiratory arrest in animals and respiratory depression in an infant.³

A fatal adult case is reported in the American Society of Anesthesiologists Newsletter.⁴ This patient received 2 gm. intraperitoneally with respiratory arrest within 10 minutes. Webber⁵ reported a case in which 5 gm. was instilled in the peritoneal cavity, producing respiratory arrest with recovery after 15 hours of artificial . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Surgical Service, Veterans Administration Hospital, Hines, Ill., and the Departments of Surgery, Chicago Medical School and the University of Illinois.; Clinical Assistant Professor of Surgery, Chicago Medical School (Dr. Mann); Clinical Assistant Professor of Anesthesiology, Department of Surgery, University of Illinois College of Medicine (Dr. Levin).

Footnotes
Submitted for publication March 22, 1960.

This work was aided by a grant from the Upjohn Company. The neomycin used in this study was supplied by the Upjohn Company (Mycifradin).

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