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Investigations on Dynamics of Bactericidal Action of Two Quaternary Ammonium Salts
RUTH B. KUNDSIN, Sc.D.
AMA Arch Surg. 1960;81(5):789-797.
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Disinfection has been assumed to be a first-order process since Chick published "An Investigation of the Laws of Disinfection" (Chick, 1908). The studies described in this paper were conducted to determine whether 2 quaternary ammonium salts conform with this concept of a first-order reaction and also whether concentration and thermal coefficients can be determined for these compounds.
The quaternary ammonium salts are becoming increasingly popular as bactericidal agents. Because they are be- colorless, stable, and relatively nontoxic, they have lent themselves to clinical as well as industrial uses where efficient bactericides are needed. Current thought, therefore, has been completely focused on in-use applications. This is reflected in the literature in a plethora of articles on the evaluation of these compounds in innumerable situations, while little attention has been given to the basic process of disinfection.
The 2 quaternary ammonium salts were used in a study of organisms exposed to the
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
Department of Surgery, Peter Bent Brigham Hospital.
Footnotes
Submitted for publication May 9, 1960.
Supported in part by a grant from Sterling-Winthrop Research Institute, Rensselaer, N.Y.
Abridgment of a thesis submitted to the Faculty of the Harvard School of Public Health in partial fulfillment of the requirements for the degree of Doctor of Science in Hygiene in the field of Microbiology, Boston, June, 1958.
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