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Experimental and Clinical Physiological Observations

WILLIAM E. NEVILLE, M.D.; SHINOBU KAMEYA, M.D.; MUSTAFA OZ, M.D.; BYRON BLOOR, M.D.; GEORGE H. A. CLOWES, JR., M.D.

AMA Arch Surg. 1961;82(1):108-119.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The use of hypothermia in conjunction with a pump-oxygenator combines the benefits derived from the reduction of the metabolic demands of the tissues with the ability adequately to perfuse the entire organism after the heart ceases to function at temperatures below 25 C. Not only is a further reduction in body temperature permissible, but rewarming of the body can be easily accomplished.

The practicality of this combination was demonstrated experimentally by Gollan⁷ with the survival of animals cooled to 10 C by perfusion of the entire organism with cold and subsequently warm blood when using an oxygenator. Peirce,²¹ in animals in which the body temperature was reduced to 25 C by internal cooling and external rewarming, showed that this moderate reduction in body temperature permitted a low-flow perfusion which could satisfactorily meet the tissue demands. By this work it was also demonstrated that a temperature gradient existed within . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From The Department of Surgery, Western Reserve University School of Medicine at Cleveland Metropolitan General Hospital.

Footnotes
Submitted for publication September 22, 1960.

This work was supported in part by a grant from the Cleveland Area Heart Society.

Read before the Eighth Scientific Meeting of the International Cardiovascular Society, North American Chapter, Miami Beach, June 11, 1960.

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