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IRVING F. ENQUIST, M.D.; RICHARD ROSEN, M.D.; ROY G. AIELLO, M.D.; ETSUTARO IKEZONO, M.D.

AMA Arch Surg. 1961;82(2):281-284.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Because the exact etiology and pathogenesis of pancreatitis are unknown, definitive treatment is lacking, and the results of treatment are not entirely satisfactory. With the measures currently applied, the mortality rate from this disease is as high as 35%. For the reasons given below, hypothermia seemed to have a logical place in the treatment of this disease, and we endeavored to evaluate its use in the experimental form.

Physical-chemical laws governing the rate of chemical reactions state that the rate of the reaction is proportional to the temperature.¹ For a 10-degree rise in temperature, enzymatic reaction rates will increase by a factor of 1.1 to 5.3, usually between 2 and 3. If the temperature is increased by 10 degrees centigrade the reaction rate should double or triple, while if the temperature is decreased by 10 degrees centigrade the rate should be approximately one-half of what it was. The . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

Department of Surgery, State University of New York, Downstate Medical Center.

Footnotes
Submitted for publication May 16, 1960.

Supported by Grant No. A-3389, from the National Institute of Arthritis and Metabolic Diseases, U.S. Public Health Service.

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