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ROBERT J. HARTSOCK, M.D.; EDWIN R. FISHER, M.D.

AMA Arch Surg. 1961;82(5):674-678.

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Although squamous metaplasia of the pancreatic ducts is not uncommon, being found in 9% to 64% of pancreases routinely examined at necropsy,^1,2 squamous cell carcinoma of this organ is rare. Only 8 cases have been documented.^3-8 Sommers and Meissner⁹ failed to encounter such a lesion in a review of 142 cases of pancreatic carcinoma, although 5 instances of adenocanthoma were observed. Lowry and associates⁷ and Lawrence⁶ noted squamous metaplasia of the pancreatic ducts in their solitary case reports of primary pancreatic squamous cell carcinoma, and they postulated that the tumor developed from areas of squamous metaplasia, although this transition was not demonstrated. Wolbach and Howe,¹⁰ in 1925, noted focal changes in areas of squamous metaplasia of pancreatic ducts in vitamin-deficient rats which changes they considered to be early carcinoma. Similar changes considered to represent in situ carcinoma in areas of squamous metaplasia have not . . . [Full Text PDF of this Article]

Author Affiliations
PITTSBURGH

From the Departments of Pathology, University of Pittsburgh, and Veterans Administration Hospital.

Footnotes
Received for publication Dec. 27, 1960.

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