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S. FRANK REDO, M.D.; SIDNEY FARBER, M.D.; ROBERT E. GROSS, M.D.

AMA Arch Surg. 1961;82(5):696-712.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Atresia of the mitral valve, often reported with cases of single ventricle or the hypoplastic left heart syndrome, is an uncommon cardiac lesion. Maude Abbott¹ in her classic monograph described 5 specimens encountered in 1,000 postmortems of patients with congenital heart disease. It has been reported by Keith, Rowe, and Vlad² that it occurs in 2% of their cases of congenital heart disease, or once in 50,000 children. Teller³ referred to 88 cases he was able to collect from the literature.

The etiology of this malformation is not known, although several theories as to pathogenicity have been advanced. Among these are theories that aberrations in the usual bending of the primary cardiac tube (Spitzer^4,5,6) occurs; that there is maldirected g r o w t h of the interventricular septum (Moenckeberg⁷); that fusion between the septum primum and the endocardial cushions (Brockman⁸) takes place; that . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From The Children's Hospital Medical Center.

Footnotes
Received for publication Dec. 14, 1960.

This study was aided by grants from the Heart Institute of the National Institutes of Health and a grant from the American Heart Association.

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