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A Complicating Factor in Experimental Extracorporeal Circulation

STANLEY GIANNELLI, JR., M.D.; D. RAJ MAHAJAN, M.D.; J. ROBERT NAVARRE, M.D.; GERALD H. PRATT, M.D.

AMA Arch Surg. 1961;82(5):713-718.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a previous article, it was shown that marked splanchnic congestion, with uptake of blood from the extracorporeal circuit, usually occurred during experimental cardiopulmonary bypass perfusions.⁷ This paper presents our subsequent findings, showing that the above are part of an anaphylacticlike reaction to the homologous canine blood, used for priming the pump oxygenator. No red-cell isoagglutinins could be demonstrated, suggesting that the reactions were due to plasma incompatibility.

General Methods

The methods employed have already been described in detail.⁷ In brief, a Kay-Cross disk oxygenator and Sigmamotor pump were employed, with 100% oxygen as the oxygenating gas. The perfusions were carried out upon a scale in such a manner that an increase in weight represented the net transfer of blood from the extracorporeal circuit to the dog. Vascular pressures were monitored with U-tube manometers. Venous return was accomplished by gravity drainage. Crossmatching employed 2 drops of the recipient's . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Attending Surgeon, in Charge, Cardiovascular Surgery (Dr. Pratt).; From the Surgical Cardiovascular Research Laboratory, St. Vincent's Hospital.

Footnotes
Received for publication Dec. 27, 1960.

Presented in part before the New York Society for Cardiovascular Surgery, Feb. 15, 1960.

This work was made possible by a research grant-in-aid from the New York Heart Association.

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