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Experiments in Heidenhain Pouch Dogs

LEO CHAIKOF, M.D.; WALTER H. JANKE, M.D.; PAN C. PESAROS, M.D.; JOSEPH L. PONKA, M.D.; BROCK E. BRUSH, M.D.

AMA Arch Surg. 1961;83(1):32-41.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The advent of steroid therapy 10 years ago has resulted in a great deal of controversy as to the effects of steroids on gastric secretion and its relationship, if any, to the aggravation or production of peptic ulcer. Many authors^1-8 feel that the adrenal cortical steroids do play a part in the production of the so-called steroid-induced, or steroid-associated, ulcers, while others, such as Meltzer et al.,⁹ Kirsner,¹⁰ and Maltby¹¹ do not feel that such a relationship exists.

Since the gastric acid level is felt to play a prime role in the development of peptic ulcers, the effects of corticotropin (ACTH) and the adrenal cortical steroids on gastric acid secretion have been studied. Zubiran,^12,13 Gray,¹ Plainos and Philippu,^14,15 and Villarreal,¹⁶ have shown that ACTH, cortisone, and prednisone do cause an increase in gastric acid secretion, while others1^7-19 have not found such . . . [Full Text PDF of this Article]

Author Affiliations
DETROIT

From the Division of General Surgery, Henry Ford Hospital.

Footnotes
This paper was read at the 68th Annual Meeting of the Western Surgical Association, Detroit, Dec. 2, 1960.

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