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Syringomyelia, Diastematomyelia, and Myelomeningocele—One Disease?

W. JAMES GARDNER, M.D.; JOHN S. COLLIS, M.D.

AMA Arch Surg. 1961;83(4):638-644.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The skeletal anomalies of the Klippel-Feil syndrome are present also in the adult with syringomyelia,¹ in the adolescent with diastematomyelia,² and in the infant with myelomeningocele.¹ These anomalies, believed due to improper segmentation of the mesodermal somites in embryonal life,² consist of varying degrees and combinations of dilatation, bifid states, fusion, shortening, and curvature of the craniovertebral column, with associated deformities of the rib cage and extremities. Within the lumen of the distended craniovertebral column, the central nervous system also exhibits varying degrees of distention of its lumen (hydrocephalus and hydromyelia).^1,3

Hypothesis

This occurrence of a distended tube of neural tissue within a distended tube of bone suggests cause and effect, namely, that overdistention of the neural tube (hydrocephalus and hydromyelia or "hydrocephalomyelia") in embryonal life has resulted in distortion of the encompassing sclerotomes, which then give rise to distorted bones—that in the individual case, . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Department of Neurological Surgery, The Cleveland Clinic Foundation and The Frank E. Bunts Educational Institute.

Footnotes
Received for publication Jan. 30, 1961.

Read before the Section on Orthopedic Surgery at the 109th Annual Meeting of the American Medical Association, Miami Beach, Fla., June 13-17, 1960.

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