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Intracapillary Clotting as the Etiology of Shock
COL. ROBERT M. HARDAWAY, MC;
CAPT. FRED H. WEISS, MC
AMA Arch Surg. 1961;83(6):851-863.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Both reversible1 and irreversible2 shock have been described as a result of the intraaortic injection into dogs of incompatible blood. This substance has been shown to cause the formation of multiple capillary thrombi in the lungs, liver, bowel, and other organs.3,4 An immediate (and reversible) precipitous drop in blood pressure was shown to accompany the injection of either incompatible blood or amniotic fluid into the aorta.1 This drop was prevented in all or in part by previously heparinizing the animal. The blood pressure rose gradually over a period of 15 to 30 minutes to a normal level. This coincided with the appearance of a bleeding tendency.4,16 It was shown1 that during the period of systemic hypotension there existed a pulmonary artery and portal vein hypertension. It was postulated1 that this type of shock was due to thrombi and associated vascular spasm in the
. . . [Full Text PDF of this Article]
Author Affiliations
USA; USA
Present address of Col. Hardaway: Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington 12, D.C.; From the General Surgery Service, Martin Army Hospital; Chief, General Surgery Service (Col. Hardaway); Prespecialty Resident in General Surgery (Capt. Weiss).
Footnotes
Received for publication Feb. 17, 1961.
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