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A Double-Blind Study

RONALD F. GARVEY, M.D.; BEN J. WILSON, M.D.

AMA Arch Surg. 1961;83(6):916-920.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

There have been numerous recent clinical reports praising the effectiveness of d-pantothenyl alcohol in shortening the period of postoperative ileus. In all of the early studies the drug was administered to a group of patients as the calcium salt or in alcohol form and results were described without adequate controls.^1-8

Recently, 2 studies have utilized the double-blind technique for clinical evaluation of the drug. Haycock et al.⁹ found a significant drop in the incidence of distention and earlier appearance of peristalsis in a group of 100 patients undergoing laparotomy for various reasons. Frazer et al.¹⁰ reported a series of 100 cases evaluated by the double-blind technique in which they found earlier resumption of audible peristalsis and passage of flatus in the treated group. No late ileus occurred in the 50 treated patients, but 6 cases of late ileus were observed in the control group. It was . . . [Full Text PDF of this Article]

Author Affiliations
DALLAS, TEXAS; GRAND JUNCTION, COLO.

From the Department of Surgery, The University of Texas, Southwestern Medical School, Dallas 35, Texas.

Footnotes
Submitted for publication Jan. 28, 1961.

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