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Effect on Hepatic Blood Flow and Splanchnic Metabolism

A. DOUGLAS BENDER, M.S.; STEVEN M. HORVATH, Ph.D.

AMA Arch Surg. 1962;84(5):504-510.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A number of investigators have been interested in the circulatory response consequent to total occlusion of the thoracic aorta^{1,2,5,13,19,30,32} and the inferior vena cava,^7,8,14,17 as well as the effect of occluding both sites simultaneously.^8,10 Despite the prominent role of the splanchnic circulation as it determines or reflects changes in the over-all metabolic and hemodynamic schema, few papers^2,8,14 have dealt with the effect of these obstructions on the blood flow to this region. However, the splanchnic response to other alterations in the circulation has received a great deal of attention.^{9,12,22,24,34}

The purpose of this investigation was to study the splanchnic response to the simultaneous occlusion of the thoracic aorta and the abdominal vena cava as it is related to the over-all response, with an emphasis on the metabolic changes consequent to the altered circulation.

Materials and Methods

Sixteen adult mongrel dogs ranging in weight from 13 . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

Department of Physiology, The Lankenau Hospital, and The Jefferson Medical College.; Present address: The University of California, Santa Barbara, Calif. (Dr. Horvath).

Footnotes
Received for publication May 5, 1961.

This investigation was supported in part by Research Grant H-4190(C1) from the National Institutes of Health, U.S. Public Health Service.

Taken from a dissertation presented by Mr. Bender to the Graduate School, The Jefferson Medical College of Philadelphia, in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Physiology.

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