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Hepatic Function After Canine Liver Transplantation
JOHN C. KUKRAL, M.D.;
MARK H. LITTLEJOHN, M.D.;
RICHARD K. WILLIAMS, M.D.;
RONALD J. PANCNER, M.D.;
GEORGE W. BUTZ, JR., M.D.;
THOMAS E. STARZL, M.D.
AMA Arch Surg. 1962;85(1):157-165.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Homotransplanted canine livers can survive in recipient dogs for as long as 3 weeks.10,11 Evaluation of liver function and other tissue metabolism can be made during this time. Studies of this kind may lead to a better understanding of the homograft rejection mechanism.
Previous histological and biochemical studies in dogs following total homotransplantation of the liver have shown a marked proliferative cellular response in the organs and a progressive obstructive jaundice pattern in the blood. Total serum protein and albumin levels as well as albumin-globulin concentration showed no marked alterations as determined by ordinary laboratory methods.11 When paper electrophoretic analyses were done, a fall in albumin and a rise in  2-globulin were most characteristic.10 The availability of radioisotopic techniques for studying plasma protein metabolism prompted the present study with 2 objectives in mind: (1) to determine the rate at which the homotransplanted liver synthesizes individual
. . . [Full Text PDF of this Article]
Author Affiliations
CHICAGO
From the Surgical and Radioisotope Services, Veterans Administration Research Hospital and Northwestern University Medical School.
Footnotes
Read at the 69th Annual Session of the Western Surgical Association, San Francisco, Nov. 30, 1961.
Aided by grants from the United Fund of Northfield, Illinois, the Frederick Augustus Preston Memorial Fund for Cancer Research and U.S. Public Health Grants A5486 and A3176.
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