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J. F. RYAN, M.D.; L. F. MOCK, M.D.; BRUCE BOLASNY, B.S.; JOHN VAN PROHASKA, M.D.

AMA Arch Surg. 1962;85(1):70-73.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is reasonable to assume that in experimentally induced cancer the carcinogen localizes in the target tissue where the tumor eventually appears. Dao, Bock, and Crouch² fed single doses of 3-methylcholanthrene to female rats according to the method of Huggins³ and assayed the amount of carcinogen present in the various tissues. The only tissues which retained significant amounts of the carcinogen were breast and fat. It is a well-known fact that mammary cancer may readily be induced in the female rat by oral feeding of 3-methylcholanthrene. It is, then, an established fact that carcinoma may be produced at a distant site in the body of an experimental animal by systemic administration of any one of several carcinogens.^1,3-5

The target tissue may be altered by changing certain factors or conditions of the experimental animal. Factors which can be varied under controlled conditions are age, nutrition, and hormonal status . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgery, University of Chicago.

Footnotes
Read at the 69th Annual Session of the Western Surgical Association, San Francisco, Nov. 29, 1961. This research was supported by grants from the Ambrose and Gladys Bowyer Foundation and Mr. Burr L. Robbins.

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