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Perfusion and Intra-Arterial Infusion

JOHN S. STEHLIN, JR., M.D.; R. LEE CLARK, M.D.

AMA Arch Surg. 1962;85(1):84-94.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

During the past 4 years, regional chemotherapy has been employed in the M. D. Anderson Hospital primarily as a medium of research in cancer, and secondarily for therapeutic purposes. At present, the 2 methods of administration consist of (1) perfusion with the use of the heart-lung machine, as suggested by Klopp^5,6 and developed by Creech,^2,3 and (2) continuous intra-arterial infusion, based upon the original work of Klopp^5,6 and Bierman¹ and their co-workers, and developed by Sullivan.¹⁴ As of Dec. 1, 1961, 265 perfusions had been performed for 209 patients, and 54 infusions for 48 patients. In the conviction that major "breakthroughs" in cancer research can best be achieved by cooperation between clinicians and investigators in the basic sciences, our approach has been a multidisciplinal one, in which surgeons, radiotherapists, pathologists, biochemists, biologists, and physicists have worked together. Herein will be presented some of the investigative . . . [Full Text PDF of this Article]

Author Affiliations
HOUSTON, TEXAS

Department of Surgery, The University of Texas M. D. Anderson Hospital and Tumor Institute.

Footnotes
Read at the 69th Annual Session of the Western Surgical Association, San Francisco, Nov. 29, 1961.

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