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V. Influence of Processing Factors on Strength and Invasion by Host

NORMAN ROSENBERG, M.D.; JOHN HENDERSON, M.D.; GEOFFREY H. LORD, D.V.M., Ph.D.; JAMES W. BOTHWELL, Ph.D.; EUGENE R. L. GAUGHRAN, Ph.D.

AMA Arch Surg. 1962;85(2):192-197.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Enzyme-treated bovine arterial heterografts can function as segmental replacements in the abdominal aorta of the dog for long periods of time.^1-4 The digestion of the vessel wall with a protease, ficin, and its subsequent formalin tanning, removes almost all of the smooth muscle and elastica, leaving a nonporous, strong collagen tube which does not leak blood through its substance.

In a group of 33 dogs, 12 of which were followed for approximately 5 years, the percentage of "successful" abdominal aortic grafts decreased from 73% of 2 year survivors to 50% of those allowed to live the full duration of the study.⁴ All long-term grafts classed as "failures" were patent and unruptured at the time of final examination. Of 10 untreated controls with a 10% incidence of "success" by aortography at 2 years (1 graft), 4 were kept for 5-year evaluation. Three were failures. One was "successful" grossly, but . . . [Full Text PDF of this Article]

Author Affiliations
NEW BRUNSWICK, N.J.

From the Vascular Surgical Service, Middlesex General Hospital, and the Johnson & Johnson Research Foundation, New Brunswick, N.J.

Footnotes
Submitted for publication Aug. 28, 1961.

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