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ISA G. SALTI, M.D.; THOMAS H. WALKER, M.D.

AMA Arch Surg. 1962;85(2):238-244.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Islet-cell tumors of the pancreas occur relatively infrequently; yet their importance stems from factors involved in their symptomatology, pathological considerations, and dramatic surgical cure in many cases.

Nicholls¹ in 1902 described the first case of islet-cell adenoma. In 1927, Wilder et al.² reported a case of islet-cell tumor exhibiting severe hypoglycemic manifestations. Exploration and biopsy performed by W. J. Mayo revealed an islet-cell carcinoma and metastasis to liver and regional lymph nodes. An extract of the liver metastases produced hypoglycemia and shock when injected into rabbits. Roscoe Graham³ in 1929 removed an islet-cell tumor from the body of the pancreas of a patient with the diagnosis made preoperatively, and the patient was known to be living 22 years later even though the lesion was malignant microscopically. Cushing⁴ successfully effected a surgical cure of a benign adenoma of the pancreas in 1930. Howard et al.⁵ . . . [Full Text PDF of this Article]

Author Affiliations
HARTFORD, CONN.

From the Department of Surgery, Hartford Hospital.

Footnotes
Received for publication Sept. 19, 1961.

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