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Their Effect on Wound Tensile Strength

JOHN F. PRUDDEN, M.D.; TAKAYUKI INOUE, M.D.; LOURDES OCAMPO, Ph.D

AMA Arch Surg. 1962;85(2):245-246.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Previous work in this laboratory has shown that the local application of acid-pepsin digested bovine tracheal cartilage microparticles will accelerate the healing of experimental wounds.^1,2 This acceleration has been quantitated³ and characterized histologically.⁴ In addition, an experimental survey of a number of substances previously thought to have beneficial effects on the healing wound, and of compounds and substances prepared from cartilage, collagen, bone, or blood, revealed absolutely no beneficial results.⁵ Indeed, most of the effects were in a negative direction. This latter study was considered strong evidence for the specificity of the "cartilage effect." It indicated that an as yet unidentified, but specific, "repair-stimulating principle" was present in untreated cartilage. Furthermore, no such activity was found in such cartilage derivatives as chondromucoprotein or chondroitin sulfate.5

Following these studies on the properties of locally applied cartilage, the next step was to evaluate what, if any, effect could . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Surgery, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital in the City of New York.

Footnotes
Received for publication Nov. 13, 1961.

This research was supported by Grant A-2581 of the National Institute of Arthritis and Metabolic Diseases.

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