This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

The Effect of Host and Graft Irradiation

T. E. STARZL, M.D.; G. W. BUTZ, JR., M.D.; D. R. BROCK, M.D.; J. T. LINMAN, M.D.; W. T. MOSS, M.D.

AMA Arch Surg. 1962;85(3):460-464.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

With homografts of various tissues and organs, systemic histologic changes in the host animal are not usually detectable. Recently, however, in studying whole-organ homografts of the canine liver, widespread changes which were coincident with rejection were found in host organs.⁶ The changes consisted of round cell infiltration and mesenchymal tissue proliferation. They were found in bone marrow, lung, kidney, and other tissue and organs which are constituents of the reticuloendothelial system.

From the information available, it was not possible to determine if these changes were part of an exaggerated host-versus-graft rejection process, or if they resulted from an attempt by the graft to repudiate the host (graft-versus-host reaction). In the present report, an attempt was made to study this point by rendering either the graft or host animal incapable of immunologic activity by preoperative ionizing irradiation.

Methods

Adult mongrel dogs weighing 15 to 20 kg. were used. The animals . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

Markle Scholar (Dr. Starzl).; From the Department of Surgery, Northwestern University Medical School.

Footnotes
Received for publication Nov. 13, 1961.

Aided by Grant A-3176 from the U.S. Public Health Service.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?