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The Effects on Isolated Perfused Guinea Pig Hearts

S. FRANK REDO, M.D.

AMA Arch Surg. 1962;85(3):483-491.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Experimental and clinical cardioplegia has been achieved by various techniques including potassium citrate or chloride, acetylcholine, Sealy's mixture (K citrate plus MgSO₄), anoxia, or hypothermia. Arrest has been maintained as long as 1 hour in the isolated guinea pig heart,¹ and up to 58 minutes in patients as reported by Effler.²

Review of the literature in this field shows that little had been reported regarding prolonged periods of elective cardiac arrest. Since it is possible that the repair of complicated or multiple cardiac defects could require long periods of cardiac arrest, the present study was undertaken to evaluate the effects of extended periods of cardioplegia on the mechanical and electrical activity of the isolated guinea pig heart. Arrest was achieved using potassium citrate, Sealy's mixture, acetylcholine, A.C.D. solution, anoxia, or hypothermia.

Materials and Methods

Guinea pig hearts were removed and perfused as isolated preparations in the manner . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Surgery, The New York Hospital-Cornell Medical Center.

Footnotes
Received for publication Nov. 24, 1961.

This study was supported in part by a grant from the New York Heart Association and in part by a grant from the United States Public Health Service (H-4131).

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