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WILLIAM C. SHOEMAKER, M.D.; LYNDON B. FITCH, M.D.

AMA Arch Surg. 1962;85(3):492-496.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Diffuse congestion of capillaries and venules in visceral areas has been described by Moon¹ as the lesion of hemorrhagic shock. Wiggers² regarded pathologic changes having real bearing on the functional derangements of hemorrhagic shock to be the firmly contracted spleen and distinctive changes in intestinal mucosa; that is, hyperemia, congestion, edema, and petechial hemorrhage. More recently, attention has been focused on acute tubular necrosis, the renal lesion of shock from hemorrhage and injury. Fine³ and others, however, have come to the conclusion that the liver is the locus of the primary defect of irreversible hemorrhagic shock.

In the present study histologic observations were made on tissues from dogs subjected to hemorrhagic shock. A hepatic lesion was consistently observed in animals subjected to hemorrhage and transfusion of shed blood. Criteria differentiating the observed lesion from chronic passive congestion or hyperemia are proposed.

Methods and Materials

Gross and microscopic . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Departments of Surgical Research and Pathology, Michael Reese Hospital and Medical Center.

Footnotes
Submitted for publication Nov. 30, 1961.

Supported in part by United States Public Health Service Grants H-4809, H-6722 and A-3115, and The Charles H. and Rachel M. Schwab Memorial Foundation.

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