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An Experimental Comparison After Total-Body Perfusion in Dogs

RICHARD GOLDMAN, M.D.; ROBERT P. HOHF, M.D.

AMA Arch Surg. 1962;85(3):497-502.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There have been several reports on the effectiveness of protamine and hexadimethrine (Polybrene) in neutralizing the effects of heparin. Parkin and Kvale¹ showed in rabbits with no extracorporeal circulation that clotting times returned to normal at a 1.5:1 dose of protamine to heparin in 5 minutes. In 1953, Preston and Parker² reported on the effects of hexadimethrine on the clotting time in peptone shock and in experimental radiation injury. They found that in the normal animal 7.5 mg. hexadimethrine neutralized 10 mg. of heparin in vivo. In peptone shock, when the coagulation time was prolonged to 56 minutes or more, hexadimethrine in doses of 0.9 to 2.2 mg. per kilogram restored the coagulation time to approximately control levels within a few minutes. In vitro studies showed that the shortest clotting time occurred when the amount of protamine and heparin exactly neutralized each other. If either was in excess, . . . [Full Text PDF of this Article]

Author Affiliations
EVANSTON, ILL.

From the Departments of Surgery, Evanston Hospital Association and Northwestern University Medical School.

Footnotes
Submitted for publication Dec. 6, 1961.

Supported by grants from the Chicago Heart Association and the Dee Fund of the Evanston Hospital Association.

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