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Effect of Local Trauma and Ischemia

K. P. ROBINSON, F.R.C.S.; EVERETT HOPPE

AMA Arch Surg. 1962;85(5):720-724.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Langenbeck is reported by Paget¹ to have said,

What is it that decides what organs shall suffer in a case of disseminated cancer.... When a plant goes to seed its seeds are carried in all directions but they can only live and grow if they fall on congenial soil.

This concept of the relation between the circulating tumor cell and the organ in which it becomes arrested has persisted to the present day. It is of practical importance to know more about this relation and the local factors which may influence it.

While Engell,² Cole et al.,³ and others have demonstrated the presence of circulating tumor cells, and Wood⁴ and Zeidman⁵ have investigated the in vivo micropathology of the arrested tumor cell, there is little known about the local factors which determine whether a cell at one site will become a metastasis, while at another . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the University of Illinois, College of Medicine, Department of Surgery, Chicago.

Footnotes
Submitted for publication June 10, 1962.

This study was supported by an award from the Peel Medical Trust, London; a grant from the University of Illinois Foundation 50-57-35, and a grant from the United States Public Health Service.

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