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ADOLPH YATES, M.D.; BERNARD FISHER, M.D.

AMA Arch Surg. 1962;85(5):827-836.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

While the technique of isolated organ and limb perfusion in humans, pioneered by Ryan, Creech, et al.,^1-4 has been employed in cancer chemotherapy for several years,^5-10 controlled studies with this modality, either experimental or clinical, have been few. In the human, variables such as size, age, location, degree of malignancy of tumors, and host factors preclude the attainment of precise information. Data obtained in the laboratory^11-16 relevant to perfusion of dogs has been primarily concerned with perfusion techniques and the toxic effects of antitumor drugs on normal tissues. Because of the rare spontaneous tumor occurrence and inability to grow transplanted tumors in such animals, perfusion of tumors in vivo has not been possible. Knock¹⁷ and Buckner et al.¹⁸ described rabbit limb perfusion, the report of the former being principally a description of technique, while that of the latter is confined to an evaluation of perfusion . . . [Full Text PDF of this Article]

Author Affiliations
PITTSBURGH

From the Department of Surgery, Laboratory of Surgical Research, University of Pittsburgh School of Medicine.

Footnotes
Presented at the 19th Annual Meeting of the Central Surgical Association, Cincinnati, Feb. 21-24, 1962

Aided by USPHS Grant No. CY-5949 and American Cancer Society Institutional Grant No. IN-58.

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