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Changing Concepts as a Result of Advances in Hematology

WILLIAM B. ASHBY, M.B., Ch.B., F.R.C.S. (Ed.); WALTER F. BALLINGER, II, M.D.

AMA Arch Surg. 1962;85(6):913-927.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Recent years have seen several advances in the surgery of the spleen. Steroid therapy has modified the role of splenectomy in acquired hemolytic anemia and idiopathic thrombocytopenic purpura. Red cell survival studies have given a clearer understanding of basic mechanisms in leukemia, thalassemia major (Cooley's anemia) and myelofibrosis and have led to more clearly defined indications for splenectomy. Better understanding of the pathology of congestive splenomegaly has caused a revision of the indications for splenectomy in that condition.

Few surgeons have concentrated experience with less common conditions for which splenectomy is advised, and there is still confusion in the use of terms such as hypersplenism, splenic anemia, and Banti's disease.

The purpose of this review is to:

1. Provide a clearer understanding of the basic mechanisms of certain conditions for which splenectomy is advised. This of necessity involves an explanation of the terms hypersplenism and Banti's disease.

2. Present . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

Markle Scholar in the Medical Sciences (Dr. Ballinger).; From the Department of Surgery, Jefferson Medical College.

Footnotes
Submitted for publication Sept., 1961.

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