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MICHAEL S. MADELOFF, M.A., M.D.; FRANKLIN D. SCHWARTZ, M.D.; FRANCIS J. BORGES, M.D.; SAMUEL T. R. REVELL, JR., M.D.; JOHN D. YOUNG, JR., M.D.

AMA Arch Surg. 1962;85(6):994-998.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The introduction, by Howard and his group in 1953,^1,14 of the relatively simple split-function test formulated, for the first time, a rational approach to the evaluation of hypertension of unilateral renal origin. Since that time, it has become apparent that the original criteria had been inadequate for diagnosis in a number of cases; and, therefore, many modifications have been proposed.^2-13 These have undoubtedly added a substantial degree of accuracy of diagnosis; but, unfortunately, they have eliminated the relative simplicity of the test.

In the course of our study of hypertension by means of complete differential renal clearances,¹¹ it became apparent that certain changes in the differential excretion of sodium and water were produced by the infusion of inulin and para-aminohippuric acid (PAH) in 5% dextrose and water. A method, therefore, may now be available for combining the better features of both types of tests; i.e., simplicity and . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

Public Health Service Research Fellow of the National Heart Institute (Dr. Schwartz).; From the Division of Renal Disease and Hypertension and the Divison of Urology of the Departments of Medicine and Surgery, respectively, of the University of Maryland School of Medicine and the University Hospital, Baltimore.

Footnotes
Submitted for publication Jan. 15, 1962.

This work has been published previously in abstract form in the Proceedings of the American Federation for Clinical Research, April, 1961.

This study was supported in part by National Institutes of Health Research Grant H-3242 and Training Grant HTS-5348.

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