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Cinefluorographic and Hemodynamic Studies

ROBERT E. WHALEN, M.D.; IVAN W. BROWN, JR., M.D.; WIRT W. SMITH, M.D.; HENRY D. McINTOSH, M.D.; GEORGE MARGOLIS, M.D.

AMA Arch Surg. 1963;86(1):118-125.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The large numbers of patients who have successfully undergone surgery utilizing various combinations of extracorporeal circulation and hypothermia testify to the efficacy of the combination of these techniques. The addition of hypothermia has led to lowered tissue metabolic demands, and thus, perfusion at relatively low flows or circulatory arrest has seemed practical. However, recent clinical reports^1,2 and experimental studies^3-5 suggest that hypothermia may not provide as large a margin of safety in preventing tissue damage when low-flow perfusion or circulatory arrest are used as had been previously hoped.

Recently Brown et al. reported their experience with combined deep hypothermia and extracorporeal circulation in dogs. These authors were particularly interested in the neurologic status and pathologic findings in dogs surviving perfusion. It was noted that a majority of dogs who survived low-flow perfusion with deep hypothermia developed a characteristic neurologic syndrome. The major features were hind leg weakness or . . . [Full Text PDF of this Article]

Author Affiliations
DURHAM, N.C.; RICHMOND, VA.

This work was completed during the tenure of a Postdoctoral Fellowship (Dr. Whalen), from the National Heart Institute, U.S. Public Health Service.; From the Departments of Medicine and Surgery, Duke Medical Center, Durham, and the Department of Pathology, Medical College of Virgina, Richmond.

Footnotes
Read before the 10th Scientific Meeting of the International Cardiovascular Society, North American Chapter, Chicago, June 23, 1962.

Supported in part by Grants H-6960, H-4807, H-4702, and B-2266 from the National Institutes of Health, U.S. Public Health Service, and the Grants-in-Aid Committee of the United Medical Research Foundation.

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