This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (1)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Independent Variables

CHARLES C. FRIES, M.D.; ANITA M. FRIES, R.N.; SIGMUND A. WESOLOWSKI, M.D.

AMA Arch Surg. 1963;86(1):13-21.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

During our experiences with total body perfusion, using extracorporeal heart-lung bypass, we noted unexplained variations in the response of peripheral vascular resistance to standard test doses of vasomotor drugs. Further experimentation was performed using the mature dog and our heart-lung bypass apparatus designed previously for the study of the role of the pulse in maintenance of the systemic circulation.¹² The arterial inflow to the animal was a continuous, pulseless, gravity perfusion at an essentially constant blood pressure. The present experiments are predicated on the following concepts: (1) Peripheral vascular tone is defined as the effective state of constriction or dilation of the peripheral vascular tree during a given steady state perfusion; it can be described by the ratio of the measured blood pressure and flow. (2) Peripheral vascular reactivity is defined as the change in the pressure-flow ratio following the introduction of some stimulus, such as a vasomotor drug. . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

From the Vascular Surgical Service, Department of Surgery, State University of New York Down-state Medical Center, Brooklyn.

Footnotes
Read before the 10th Scientific Meeting of the International Cardiovascular Society, North American Chapter, Chicago, June 23, 1962.

Supported in part by the New York Heart Association Grant 290.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?