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Differential Effects of Rabbit and Guinea Pig Sera

T. J. McNAIR; EVERETT HOPPE; W. H. COLE

AMA Arch Surg. 1963;86(2):196-198.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Several authors^2,4,7,8 have described a filterable virus capable of inducing tumors in a wide range of hosts (mice, hamsters, rats). Likewise, it has been shown that formation of antibodies is induced by some of these viruses, so that treated animals are protected against inoculation with the live virus^3,6,8 Stewart and Eddy⁸ induced this immunity in hamsters by injecting a mixture of virus culture, culture fluid, and immune serum which had been incubated overnight at 4 C.

Herein we are reporting some experiments in which Sarcoma 180 cells were incubated in rabbit serum and a similar number of cells in guinea pig serum, followed by inoculation into Swiss mice subcutaneously. Nineteen days after the last of 3 such injections, these mice were challenged with a fresh suspension of 440,000 Sarcoma 180 cells.

Materials and Methods

A suspension of Sarcoma 180 cells was prepared by mincing 1 gm. of . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

Department of Surgery, University of Illinois, College of Medicine.

Footnotes
Submitted for publication May 4, 1962.

Aided in part by a grant (C4-3482) from the National Institutes of Health, U.S. Public Health Service, and from the Abbott Laboratories.

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