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Transplantation After Preservation at Low Temperature

GEORGE D. ZUIDEMA, M.D.; WILLIAM D. BURTON, M.D.

AMA Arch Surg. 1963;86(2):246-249.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This experiment was undertaken to develop a method of in vitro preservation of tissue in a viable state. Skin, bone, dura mater, and blood vessels have been transplanted successfully after periods of in vitro storage, but these tissues are usually preserved in a nonviable state and have been selected more for their structural or physical properties than for their physiological function. Tissue culture techniques have, of course, been highly developed, and strains of normal and neoplastic cells have been maintained for long periods of time. Certain aspects of tissue culture work have been applied to this problem in an effort to preserve thyroid tissue in vitro at low temperature and to demonstrate its viability upon reimplantation in the donor animal.

Thyroid tissue was selected because viability could be demonstrated by its uptake of radioactive iodine as well as by histological study. Endocrine tissue is well suited for transplantation because it . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH.

John and Mary R. Markle Scholar in Medical Science, U.S. Public Health Service Career Development Awardee, AM-K3, 13,702 (Dr. Zuidema).

Footnotes
Submitted for publication June 26, 1962.

Supported by American Cancer Society Institutional Research Grant IN-40 B.

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