This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (80)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

H. B. SHUMACKER, JR., M.D.; I. MANDELBAUM, M.D.

AMA Arch Surg. 1963;86(3):384-387.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Certain experimental and clinical observations indicate that the local use of antibiotics may be more effective in some situations than their systemic administration. Poth, for example, showed that when neomycin was added to a 10% suspension of human feces no bacteria could be cultured.¹ Furthermore, if mice were inoculated intraperitoneally with 1 cc. of 10% human feces none survived, while in contrast, all survived if neomycin were given intraperitoneally within 1 hour of the fecal injection. Poth also demonstrated that the instillation of neomycin solution is effective in sterilizing the human intestinal tract within 30 minutes. Sterilization of peritoneal fluid has also been noted following intraperitoneal instillation of antibiotics in patients with acute bacterial peritonitis secondary to perforation of the gastrointestinal tract.²

Because of these considerations antibiotics have been used intraperitoneally by us and our associates for several years in patients with peritoneal contamination and in patients undergoing . . . [Full Text PDF of this Article]

Author Affiliations
INDIANAPOLIS

From the Department of Surgery, Indiana University School of Medicine.

Footnotes
Submitted for publication Aug. 24, 1962.

Aided by a grant from the James Whitcomb Riley Memorial Association.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?