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Effect of Epsilon-Amino-Caproic Acid

JOHN S. BELKO, B.S.; RICHARD WARREN, M.D.; ELLEN E. REGAN, B.A.; ROBERT G. SIMPSON

AMA Arch Surg. 1963;86(3):396-401.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The introduction of therapeutic preparations that produce a fibrinolytic state has created a need for a neutralizing agent or inhibitor that can be used in any emergency in the event of hemorrhage resulting from over-dosage of the drugs or hypersensitivity to them.

In 1953, De Vries⁶ demonstrated the activity of amino acids as inhibitors of fibrinolytic activity. In 1959 Okamoto and his co-workers¹⁵ published an account of their earlier discovery of -amino-caproic acid (EACA) as a potent inhibitor of fibrinolysis. They named the product Ipsilon.^5,21 Sarker,¹⁹ Sjoerdsma,²⁰ Ablondi,² and Alkjaersig³ substantiated these findings.

The mechanism of inhibition of lysis by -amino-caproic acid has been shown to be one of preventing the activation of plasminogen rather than the neutralization of fibrinolytic activity of plasmin.^1-3,10,8

The creation of a bleeding state in dogs by the use of plasmin or an activator, and its subsequent . . . [Full Text PDF of this Article]

Author Affiliations
WEST ROXBURG, MASS.

Chemist, Research Laboratory, Veterans Administration Hospital (Mr. Belko); Chief, Surgical Service, Veterans Administration Hospital, and Clinical Professor of Surgery, Harvard Medical School (Dr. Warren).; From the Department of Surgery, Harvard Medical School and the Surgical Service, Veterans Administration Hospital.

Footnotes
Submitted for publication Sept. 4, 1962.

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