This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

L-Ascorbic-1-C14 Acid Catabolism and Tissue Retention Following Wounding in Young and Older Guinea Pigs

ARTHUR F. ABT, M.D.; SUSANNE VON SCHUCHING, Ph.D.

AMA Arch Surg. 1963;86(4):627-632.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The increasing longevity of the Veteran patient has created interest in all aspects of aging. In previous studies on young guinea pigs we have noted that ascorbic acid is essential, both for the production of connective tissue to insure immediate postoperative healing, as well as for the maintenance of previously formed scar tissue.

Because there has been a traditional reluctance among surgeons to operate on the older human, it seemed important to make studies on aged animals, similar to those reported by us on growing animals.^1-5

We realize that conclusions from our studies on the guinea pig concerning the influence of vitamin C on wound healing at various ages cannot be directly applied to the human. However, the results here presented may be applicable to man, since we have demonstrated that the metabolism of both species is similar in degree.^6,7

Methods and Diets

The exact life span of . . . [Full Text PDF of this Article]

Author Affiliations
MARTINSBURG, W. VA.

Radioisotope Service, Veterans Administration Center.

Footnotes
Submitted for publication Nov. 13, 1962.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?