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ENOCH C. McREYNOLDS, M.D.; ALAN THOROGOOD, M.B., B.S.; LUCIEN E. MORRIS, M.D.

AMA Arch Surg. 1963;86(4):633-640.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1956 Raventós reported an investigation of the pharmacologic behavior of a fluorinated hydrocarbon (2 bromo-2 chloro-1, 1, 1-trifluoroethane) which was found to be a potent inhalation anesthetic.¹ The first clinical trials reported by Johnstone,² Bryce-Smith, and O'Brien³ were quickly followed by further favorable reports.^4-8 Since then this agent, halothane (Fluothane), has been both enthusiastically received as a clinical anesthetic and subjected to extensive laboratory and clinical investigation.⁹ Although one of the advantages of halothane is its nonflammability, inhalation anesthetic agents with which it has been commonly compared clinically are ether and cyclopropane, both of which are flammable and explosive, thereby limiting their comparable use under some conditions. Since their physical characteristics are quite different from halothane, dissimilar means of administration are usually used. Pharmacologic effects are also quite diverse. Chloroform, on the other hand, is a most logical agent for clinical comparison with . . . [Full Text PDF of this Article]

Author Affiliations
SEATTLE

Present address: Bristol, Tenn. (Dr. McReynolds); now Consultant Anesthetist, Colchester, England (Dr. Thorogood); Director of Anesthesia Research Laboratories, Providence Hospital, Seattle (Dr. Morris).; Department of Anesthesia, King County Hospital, University of Washington, Seattle.

Footnotes
Submitted for publication Nov. 19, 1962.

Supported in part by a grant from the Office of Civil and Defense Mobilization. The Fluothane was supplied by Ayerst Laboratories.

This is an unevaluated report made under an Office of Civil and Defense Mobilization contract and distributed for information purposes. Contents do not necessarily reflect OCDM policy.

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