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Cholelithiasis and Spherocytosis in Peromyscus
W. KNOX FITZPATRICK, JR., MD;
WALTER J. BURDETTE, MD;
RALPH R. HUESTIS, PhD
AMA Arch Surg. 1963;86(6):897-903.
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Gallstones have occurred in laboratory animals only after certain artificial conditions are met. Shortly after 1950, it was found that a colony of deer mouse (Peromyscus maniculatus) occasionally bore gallstones spontaneously.1 This provided a unique opportunity to investigate gallstones occurring naturally in a suitable laboratory animal. A colony of 6,416 of these animals was maintained over an eight-year period, and examination of the records of this colony has revealed groups in which there is a higher incidence of gallstones than in others. Maintenance of this colony provides the opportunity to study chemical and hormonal as well as genetic factors influencing formation of stones in this species.
The American deer mouse is one of the most widely distributed animals on the North American continent. It ranges from the Atlantic to the Pacific oceans and from the Arctic Circle to the Isthmus of Tehuantepec. Peromyscus maniculatus has been modified into more
. . . [Full Text PDF of this Article]
Author Affiliations
SALT LAKE CITY
Department of Surgery and Laboratory of Clinical Biology, University of Utah College of Medicine and Veterans Administration Hospital, Salt Lake City, and Department of Biology, University of Oregon, Eugene.
Footnotes
Presented at the 70th Annual Session of the Western Surgical Association, Nov 29-Dec 1, 1962.
Aided by a grant from the National Institutes of Health, United States Department of Health, Education, and Welfare.
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