This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (13)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

WILLIAM H. MARSHALL, MD; EVERETT T. HOPPE, BS; FRED STARK, MD

AMA Arch Surg. 1963;86(6):932-939.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Present research in the chemotherapy of malignant disease has followed two general patterns. The first and most extensively pursued has been attempts to discover new and better therapeutic agents. The second approach has been attempts to develop methods of increasing the therapeutic effectiveness of the presently available agents by trying to decrease their systemic toxicity or to increase their therapeutic ratio. Mechlorethamine (nitrogen mustard), the oldest of the present day chemotherapeutic agents, has been the most intensively studied with this latter objective in mind.

Klopp¹ first demonstrated an increase in therapeutic effect and at the same time a decrease in systemic toxicity of mechlorethamine when it was administered by the intra-arterial rather than the intravenous route. This was almost simultaneously confirmed by Bierman et al.² Several recent investigators have reported attempts to reduce the systemic toxicity of mechlorethamine by the simultaneous infusion of cysteine or thiosulfate solutions. . . . [Full Text PDF of this Article]

Author Affiliations
LOUISVILLE, KY

Instructor in Surgery, Price Fellow in Surgical Research, Department of Surgery, University of Louisville School of Medicine (Dr. Marshall); Department of Surgery, University of Illinois College of Medicine, Chicago (Dr. Stark and Mr. Hoppe).

Footnotes
Presented at the 70th Annual Session of the Western Surgical Association, St. Louis, Nov 29-Dec 1, 1962.

Supported by a grant from the Research Committee, College of Medicine, University of Illinois.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?