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Effect of Total Denervation on Cardiovascular Responses

LAZAR J GREENFIELD, MD; PAUL A. EBERT, MD

AMA Arch Surg. 1963;87(5):717-721.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The effects of hypoxia on the circulatory system involving changes in heart rate, cardiac output, and arterial blood pressure have received considerable attention. Most studies have been made in intact anesthetized dogs by varying the gas mixture used to ventilate the animal, and changes in cardiac function have been attributed to both the direct effect of oxygen deficit on the heart and to reflex neurogenic stimuli. Studies using separate perfusion systems for the systemic and cardiac circulations have shown little initial effect on the perfused heart with moderately hypoxic blood, whereas isolated perfusion of the carotid receptors with desaturated blood results in bradycardia during the period of hypoxia to the chemoreceptors.³ Similarly, Austen and associates¹ have shown that systemic hypoxia could cause severe cardiac arrhythmia even when the heart was receiving fully oxygenated blood. It was originally shown by Harrison and coworkers⁹ that thoracic sympathectomy did not . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Surgery, The Johns Hopkins University and Hospital.

Footnotes
Submitted for publication April 1, 1963.

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