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Brain and Face Tumors

M. S. MAHALEY, JR., MD; GUY L. ODOM, MD; BARNES WOODHALL, MD

AMA Arch Surg. 1963;87(5):765-774.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

When regional chemotherapeutic perfusions of neoplasms of the brain and face were begun, histological examination of specimens following perfusion was undertaken in order to evaluate the effect of the anticancer drug used. Sixty patients have undergone carotid perfusions, and half of these have had postperfusion histological sections on one or more occasions. This paper reports local histological changes following regional chemotherapy and the relationship between this histopathology and the therapeutic response.

Method

Regional Perfusion Technique.

—The extracorporeal perfusion circuit consisted of a dual channel pump, a bubble oxygenator, a heat exchanger, a venous reservoir bottle, and a bubble trap, interconnected with plastic tubing.¹ Donor blood was the perfusate for all internal carotid and some external carotid perfusions. Dextran was used in place of blood in some external carotid perfusions. One hundred per cent oxygen was used in the oxygenator, and the heat exchanger was maintained at 45 C . . . [Full Text PDF of this Article]

Author Affiliations
DURHAM, NC

From the Division of Neurosurgery, Duke University Medical Center.

Footnotes
Submitted for publication April 8, 1963.

Supported by USPHS grants CA-04751-04 and H-3582 (Center for Study of Aging).

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