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Further Studies

HIROSHI HAYASAKA, MD; JOSEPH F. O'MALLEY, MD; JOHN M. HOWARD, MD

AMA Arch Surg. 1963;87(5):861-865.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Within recent years, several investigators have utilized corticosteroids in the treatment of shock due to Gram-negative organisms. Bein and Jaques¹ reported a lifesaving effect in cats when aldosterone was given intravenously in a single injection after an otherwise fatal injection of the endotoxin of Proteus.

Previous work² in this laboratory showed that 46% of 46 cats survived when given a single intravenous injection of aldosterone (0.1 mg/kg), 30 minutes after receiving intravenously an otherwise fatal dose of the endotoxin of E scherichia coli. The purpose of the current investigation has been to further explore this antitoxic effect and if possible to extend its sphere of potential usefulness.

Methods

Healthy cats of either sex weighing 1.5-4.5 kg were used. A femoral cut down exposed the artery for recording blood pressure and the vein for intravenous injections. The cats were anesthetized with diallybarbituric acid (Dial)-urethane (1.1 ml/kg) intravenously. The temperature . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Surgery, Hahnemann Medical College.

Footnotes
Submitted for publication May 28, 1963.

Supported by a grant (A1-04064) from the Institute of Allergy and Infectious Diseases, National Institutes of Health.

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